Oversecretion of IL-1β, IL-6, and TNF-α

There are many clinical conditions associated with cytokine effects, which may be negative. Cytokines IL-1β, IL-6, and TNF-α can exert systemic action, therefore oversecretion of these cytokines enable to trigger dangerous autoinflammatory syndromes known as a cytokine storm as well as toxic schock syndrome.