CELLS OF THE IMMUNE CELLS

Innate Lymphoid Cells (ILC)

Group

Cells

Cytokines and mediators

Activity

 1st group

Thymic NK cells

IFN-γ

T-cell lymphopoiesis

NK cells (often considered as a separate lineage)

IFN-γ, perforin, and granzymes

Natural cytotoxicity

ILC1

IFN-γ

Defense from intracellular pathogens, tumors

 2nd group

ILC2

IL-5, IL-9, IL-13, TSLP, and amphiregulin

Allergic inflammation, defense from helminths, wound repair, Th2 regulation

 3rd group

LTi cells (often considered as a separate lineage)

TNF-β, IL-17, and IL-22

Development of lymphoid cells including Peyer's patches, intestinal homeostasis, defense from extracellular pathogens

NCR+ILC3 (IL—22)

IL-22

Maintenance of epithelium integrity, Th22 regulation

NCR-ILC3 (IL—17)

IFN-γ and IL-17

Defense from extracellular pathogens, Th17 regulation


Innate Lymphoid Cells (ILCs) is a collective term for neither T cells nor B cells. ILCs are involved in the innate immunity, inflammation, lymphoid tissue development, and immunoregulation. Among described ILCs, one ILCs subgroup, NK cells, have been identified many years ago.

©V.V.Klimov